For research use only. Not for therapeutic Use.
HODHBt (Cat No.: I028828) is a small-molecule compound known for its ability to enhance immune responses, particularly through modulation of IL-15 signaling pathways. It has been studied for its potential in “shock-and-kill” strategies aimed at reactivating latent HIV reservoirs by boosting natural killer (NK) cell and T-cell activity. HODHBt acts as a latency-reversing agent (LRA), making it valuable in HIV cure research. Its immunomodulatory effects also hold promise in cancer immunotherapy and other applications involving immune cell activation.
| CAS Number | 28230-32-2 |
| Synonyms | 3-hydroxy-1,2,3-benzotriazin-4-one |
| Molecular Formula | C7H5N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C7H5N3O2/c11-7-5-3-1-2-4-6(5)8-9-10(7)12/h1-4,12H |
| InChIKey | HJBLUNHMOKFZQX-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=O)N(N=N2)O |
| Reference | [1]. Macedo AB, et al. The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation. J Virol. 2022 Aug 10;96(15):e0037222. |
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