HKOH-1

• CAT Number: I045009
• CAS Number: 2031170-96-2
• Molecular Formula: C26H12Cl2I2O6
• Molecular Weight: 745.08
• Purity: ≥95%
• Synonyms: 2′,7′-dichloro-3′-hydroxy-6′-(4-hydroxy-3,5-diiodophenoxy)spiro[2-benzofuran-3,9′-xanthene]-1-one
• IUPAC Name: 2',7'-dichloro-3'-hydroxy-6'-(4-hydroxy-3,5-diiodophenoxy)spiro[2-benzofuran-3,9'-xanthene]-1-one
• InChI: InChI=1S/C26H12Cl2I2O6/c27-16-7-14-21(9-20(16)31)35-22-10-23(34-11-5-18(29)24(32)19(30)6-11)17(28)8-15(22)26(14)13-4-2-1-3-12(13)25(33)36-26/h1-10,31-32H
• InChIKey: BZWBSIJSVLAKAF-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=O)OC23C4=CC(=C(C=C4OC5=CC(=C(C=C35)Cl)OC6=CC(=C(C(=C6)I)O)I)O)Cl

HKOH-1（Cat No.:I045009）is a highly selective, turn-on fluorescent probe specifically developed for detecting hypochlorous acid (HOCl) in biological systems. Upon reaction with HOCl, HKOH-1 undergoes a chemical transformation that significantly enhances its fluorescence signal, enabling sensitive and real-time detection in live cells. It features strong selectivity for HOCl over other reactive oxygen and nitrogen species, making it ideal for probing oxidative stress and inflammation. HKOH-1 is widely used in studies of immune responses, redox biology, and HOCl-related pathologies such as atherosclerosis, infection, and cancer, providing valuable insights into disease mechanisms.