HKB99

• CAT Number: I042305
• CAS Number: 2414908-90-8
• Molecular Formula: C23H18N2O6S
• Molecular Weight: 450.46
• Purity: ≥95%
• Synonyms: 4-(azetidin-1-yl)-N-(3,4-dihydroxy-9,10-dioxoanthracen-2-yl)benzenesulfonamide
• InChI: InChI=1S/C23H18N2O6S/c26-20-15-4-1-2-5-16(15)21(27)19-17(20)12-18(22(28)23(19)29)24-32(30,31)14-8-6-13(7-9-14)25-10-3-11-25/h1-2,4-9,12,24,28-29H,3,10-11H2
• InChIKey: ZSFURBMYHHMIKE-UHFFFAOYSA-N
• SMILES: C1CN(C1)C2=CC=C(C=C2)S(=O)(=O)NC3=C(C(=C4C(=C3)C(=O)C5=CC=CC=C5C4=O)O)O

HKB99 (Cat No.: I042305) is a small-molecule compound developed as a mitochondrial-targeting agent with potent anticancer activity. It induces apoptosis by disrupting mitochondrial membrane potential and increasing reactive oxygen species (ROS) levels within cancer cells, leading to mitochondrial dysfunction and cell death. HKB99 has shown promise in preclinical models, particularly against drug-resistant and aggressive tumors. Its selective action on cancer cell mitochondria makes it a valuable tool for studying mitochondrial pathways and developing targeted therapies for malignancies with minimal toxicity to normal cells.

Reference

[1]. Liang Q, et al. HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells. Acta Pharmacol Sin. 2021 Jan;42(1):115-119.
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[2]. Huang K, et al. A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer. Cell Metab. 2019 Dec 3;30(6):1107-1119.e8.
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