For research use only. Not for therapeutic Use.
HJ445A(CAT: I040211) is a potent and selective myoferlin (MYOF) inhibitor, binding to the MYOF-C2D domain with high affinity (K_D = 0.17 μM). By targeting MYOF, a membrane-associated protein involved in cancer cell survival and metastasis, HJ445A effectively disrupts key oncogenic pathways. It exhibits strong antiproliferative activity against gastric cancer cell lines MGC803 and MKN45, with IC₅₀ values of 0.16 μM and 0.14 μM, respectively. In vivo studies demonstrate superior antitumor efficacy, highlighting its promise as a therapeutic lead. HJ445A is a valuable small-molecule tool for investigating MYOF function and advancing cancer research and drug development.
| CAS Number | 3032441-59-8 |
| Synonyms | 3-[3-ethyl-5-(4-methoxyphenyl)-1,2,4-triazol-1-yl]-N-[4-(triazol-2-yl)butyl]benzamide |
| Molecular Formula | C24H27N7O2 |
| Purity | ≥95% |
| IUPAC Name | 3-[3-ethyl-5-(4-methoxyphenyl)-1,2,4-triazol-1-yl]-N-[4-(triazol-2-yl)butyl]benzamide |
| InChI | InChI=1S/C24H27N7O2/c1-3-22-28-23(18-9-11-21(33-2)12-10-18)31(29-22)20-8-6-7-19(17-20)24(32)25-13-4-5-16-30-26-14-15-27-30/h6-12,14-15,17H,3-5,13,16H2,1-2H3,(H,25,32) |
| InChIKey | URMOEUMTLANRDL-UHFFFAOYSA-N |
| SMILES | CCC1=NN(C(=N1)C2=CC=C(C=C2)OC)C3=CC=CC(=C3)C(=O)NCCCCN4N=CC=N4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
