HIV-1 inhibitor-8

• CAT Number: I045392
• CAS Number: 2826996-78-3
• Molecular Formula: C25H21N5OS
• Molecular Weight: 439.53
• Purity: ≥95%
• Synonyms: 4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl]amino]benzonitrile
• InChI: InChI=1S/C25H21N5OS/c1-16-12-19(4-3-10-26)13-17(2)23(16)31-24-21-15-32-11-9-22(21)29-25(30-24)28-20-7-5-18(14-27)6-8-20/h3-8,12-13H,9,11,15H2,1-2H3,(H,28,29,30)/b4-3+
• InChIKey: GLFXFXOZHKJYEL-ONEGZZNKSA-N
• SMILES: CC1=CC(=CC(=C1OC2=NC(=NC3=C2CSCC3)NC4=CC=C(C=C4)C#N)C)C=CC#N

HIV-1 Inhibitor-8 (Cat No.: I045392) is a small-molecule compound designed to interfere with critical stages of the HIV-1 replication cycle. While its precise target may vary depending on structural class, such inhibitors typically act on viral enzymes such as reverse transcriptase, integrase, or protease, or disrupt viral entry or fusion processes. HIV-1 Inhibitor-8 is primarily used in preclinical research to evaluate antiviral efficacy, resistance profiles, and mechanistic pathways. It supports the development of next-generation antiretroviral therapies aimed at overcoming drug resistance and improving treatment outcomes.

Reference

[1]. Wang Z, et al. Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles [published online ahead of print, 2021 Aug 25]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01015.
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