Histamine H4 receptor antagonist-1

• CAT Number: I045180
• CAS Number: 1246207-84-0
• Molecular Formula: C30H38N8O2
• Molecular Weight: 542.68
• Purity: ≥95%
• Synonyms: 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-[(2S)-1-(dimethylamino)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1H-isoquinoline-2-carboxamide
• InChI: InChI=1S/C30H38N8O2/c1-35(2)28(39)26(17-21-7-5-4-6-8-21)33-30(40)38-12-11-22-9-10-23(18-24(22)20-38)25-19-27(34-29(31)32-25)37-15-13-36(3)14-16-37/h4-10,18-19,26H,11-17,20H2,1-3H3,(H,33,40)(H2,31,32,34)/t26-/m0/s1
• InChIKey: AVTPLFSHOMCNRC-SANMLTNESA-N
• SMILES: CN1CCN(CC1)C2=NC(=NC(=C2)C3=CC4=C(CCN(C4)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N(C)C)C=C3)N

Histamine H4 receptor antagonist-1（Cat No.:I045180）is a potent and selective blocker of the histamine H4 receptor (H4R), a G protein-coupled receptor primarily expressed on immune cells such as mast cells, eosinophils, and T cells. By inhibiting H4R signaling, it reduces chemotaxis, cytokine release, and inflammatory responses, making it valuable for studying allergy, asthma, autoimmune diseases, and chronic inflammation. This antagonist is an important research tool for elucidating H4R’s role in immune modulation and holds therapeutic potential for treating histamine-driven inflammatory disorders without affecting H1- or H2-mediated physiological functions.