For research use only. Not for therapeutic Use.
HG-7-85-01（Cat No.:I015341）is a potent multikinase inhibitor designed to target BCR-ABL, including imatinib-resistant mutants such as T315I, along with other kinases like KIT, PDGFR, and SRC family kinases. By blocking aberrant kinase signaling, it disrupts pathways critical for cancer cell survival and proliferation. HG-7-85-01 has shown strong preclinical activity in models of chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). Its broad inhibition profile makes it a valuable research tool for exploring resistance mechanisms and advancing next-generation therapeutic strategies in kinase-driven malignancies.
| CAS Number | 1258391-13-7 |
| Synonyms | 3-[2-(cyclopropanecarbonylamino)-[1,3]thiazolo[5,4-b]pyridin-5-yl]-N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide |
| Molecular Formula | C31H31F3N6O2S |
| Purity | ≥95% |
| IUPAC Name | 3-[2-(cyclopropanecarbonylamino)-[1,3]thiazolo[5,4-b]pyridin-5-yl]-N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide |
| InChI | InChI=1S/C31H31F3N6O2S/c1-2-39-12-14-40(15-13-39)18-22-8-9-23(17-24(22)31(32,33)34)35-28(42)21-5-3-4-20(16-21)25-10-11-26-29(36-25)43-30(37-26)38-27(41)19-6-7-19/h3-5,8-11,16-17,19H,2,6-7,12-15,18H2,1H3,(H,35,42)(H,37,38,41) |
| InChIKey | VTWWRKFUHCSCEW-UHFFFAOYSA-N |
| SMILES | CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC=CC(=C3)C4=NC5=C(C=C4)N=C(S5)NC(=O)C6CC6)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
