For research use only. Not for therapeutic Use.
Hex (hexokinase inhibitor) (Cat No.: I045440) is a small-molecule glycolysis inhibitor that targets enolase, an enzyme catalyzing the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway. By blocking this step, Hex disrupts energy production, particularly in cells reliant on glycolysis, such as certain cancer cells. It has been studied for its potential in targeting tumors with ENO1 deletions (synthetic lethality) and in metabolic research to explore glycolytic control. Hex is also used as a biochemical tool to investigate cancer metabolism and therapeutic vulnerabilities.
| CAS Number | 2004714-32-1 |
| Synonyms | (1-hydroxy-2-oxopiperidin-3-yl)phosphonic acid |
| Molecular Formula | C5H10NO5P |
| Purity | ≥95% |
| InChI | InChI=1S/C5H10NO5P/c7-5-4(12(9,10)11)2-1-3-6(5)8/h4,8H,1-3H2,(H2,9,10,11) |
| InChIKey | DVZQUMSQEGOYMX-UHFFFAOYSA-N |
| SMILES | C1CC(C(=O)N(C1)O)P(=O)(O)O |
| Reference | [1]. BOARD OF REGENTS, et al. Enolase inhibitors and methods of treatment there with. WO2016145113A1 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
