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HERNANDEZINE

HERNANDEZINE

  • CAT Number: T000065
  • CAS Number: 6681-13-6
  • Molecular Formula: C39H44N2O7
  • Molecular Weight: 652.788
  • Purity: ≥95%
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<p>
HERNANDEZINE(cas 6681-13-6) is probably a calcium antagonist, a platelet aggregation inhibitor an anti-inflammatory and an analgesic.
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Bisbenzylisoquinoline alkaloid<!–C<sub>39</sub>H<sub>44</sub>N<sub>2</sub>O<sub>7</sub>–>, from plants of the <i>Thalictrum</i> genus, Ranunculaceae.<br />
<p>
It inhibits rat platelet aggregation induced by collagen, ADP, A23187 and arachidonic acid and inhibits A23187-induced concentration increase of cytosolic free calcium in human platelet.
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Catalog Number T000065
CAS Number 6681-13-6
Molecular Formula

C39H44N2O7

Purity 95%
Solubility In chloroform; Not well in ethanol, methanol
Storage Store at +4°C, in dark place.
InChI InChI=1S/C39H44N2O7/c1-40-16-14-25-21-32(43-4)34-22-28(25)29(40)18-23-8-11-26(12-9-23)47-33-20-24(10-13-31(33)42-3)19-30-35-27(15-17-41(30)2)36(44-5)38(45-6)39(46-7)37(35)48-34/h8-13,20-22,29-30H,14-19H2,1-7H3/t29-,30-/m0/s1
InChIKey FUZMQNZACIFDBL-KYJUHHDHSA-N
SMILES CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(CCN6C)C(=C(C(=C7O3)OC)OC)OC)OC)OC
Reference

– Shu-Hua Chen et al., /Calcium antagonists from traditional Chinese herbs./ Drug News and Perspectives (1990). 3(7):425-428<br />
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– M. Shamma et al., Chem. Comm., (1966). 7<br />
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– Sadritdinov, /Alkaloid inflammatory effects of Hernandezine and some of its action mechanisms./ Alkaloid and heart glycoside pharmacology, Tashkent, (1971) (Russian). 117-120<br />
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