For research use only. Not for therapeutic Use.
Hemicholinium-3 (Cat No.:I028681) is a potent inhibitor of high-affinity choline transporters, specifically blocking the uptake of choline into presynaptic neurons. By limiting choline availability, HC-3 effectively reduces acetylcholine synthesis, making it a valuable research tool for studying cholinergic neurotransmission. It does not inhibit choline acetyltransferase directly but impairs cholinergic signaling by depleting intracellular choline levels. Hemicholinium-3 is widely used in neuropharmacology to explore mechanisms underlying learning, memory, and neurodegenerative diseases such as Alzheimer’s. Its ability to disrupt cholinergic function provides insights into synaptic transmission and neuronal communication.
| CAS Number | 312-45-8 |
| Synonyms | 2-[4-[4-(2-hydroxy-4,4-dimethylmorpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethylmorpholin-4-ium-2-ol;dibromide |
| Molecular Formula | C24H34Br2N2O4 |
| Purity | ≥95% |
| IUPAC Name | 2-[4-[4-(2-hydroxy-4,4-dimethylmorpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethylmorpholin-4-ium-2-ol;dibromide |
| InChI | InChI=1S/C24H34N2O4.2BrH/c1-25(2)13-15-29-23(27,17-25)21-9-5-19(6-10-21)20-7-11-22(12-8-20)24(28)18-26(3,4)14-16-30-24;;/h5-12,27-28H,13-18H2,1-4H3;2*1H/q+2;;/p-2 |
| InChIKey | OPYKHUMNFAMIBL-UHFFFAOYSA-L |
| SMILES | C[N+]1(CCOC(C1)(C2=CC=C(C=C2)C3=CC=C(C=C3)C4(C[N+](CCO4)(C)C)O)O)C.[Br-].[Br-] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
