Helenalin acetate

• CAT Number: I028673
• CAS Number: 10180-86-6
• Molecular Formula: C17H20O5
• Molecular Weight: 304.34
• Purity: ≥95%
• Synonyms: [(3aR,5R,5aR,8aR,9S,9aR)-5,8a-dimethyl-1-methylidene-2,8-dioxo-3a,4,5,5a,9,9a-hexahydroazuleno[6,5-b]furan-9-yl] acetate
• InChI: InChI=1S/C17H20O5/c1-8-7-12-14(9(2)16(20)22-12)15(21-10(3)18)17(4)11(8)5-6-13(17)19/h5-6,8,11-12,14-15H,2,7H2,1,3-4H3/t8-,11+,12-,14-,15+,17+/m1/s1
• InChIKey: DCNRYQODUSSOKC-HKHYKUHTSA-N
• SMILES: CC1CC2C(C(C3(C1C=CC3=O)C)OC(=O)C)C(=C)C(=O)O2

Helenalin acetate (Cat No.: I028673) is a natural sesquiterpene lactone derivative found in plants like Arnica montana. It exhibits potent anti-inflammatory, anti-cancer, and immunosuppressive properties by covalently modifying cysteine residues in key regulatory proteins, particularly inhibiting NF-κB signaling. This suppression of pro-inflammatory gene expression makes it valuable in inflammation and cancer research. The acetate form improves its stability and lipophilicity. Helenalin acetate is widely studied for its therapeutic potential in autoimmune diseases, cancer, and chronic inflammatory conditions, though its cytotoxicity requires careful handling.

Reference

[1]. Jakobs A, et al. Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300. J Biol Chem. 2016 Dec 9;291(50):26098-26108.
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