For research use only. Not for therapeutic Use.
Heclin（Cat No.:I011195）is a selective small-molecule inhibitor of HECT (Homologous to E6AP C-Terminus) E3 ubiquitin ligases, particularly targeting HECT domain-containing proteins such as NEDD4 and Smurf2. By disrupting ubiquitin ligase activity, Heclin prevents the ubiquitination and subsequent degradation of substrate proteins, thereby modulating cellular protein homeostasis. It is widely used in research to study protein turnover, signal transduction, and the role of ubiquitin-mediated regulation in cancer and neurodegeneration. Heclin serves as a valuable tool for exploring therapeutic strategies involving the ubiquitin-proteasome system and understanding E3 ligase-related disease mechanisms.
| CAS Number | 890605-54-6 |
| Synonyms | (E)-N-(4-acetylphenyl)-3-(5-ethylfuran-2-yl)prop-2-enamide |
| Molecular Formula | C17H17NO3 |
| Purity | ≥95% |
| IUPAC Name | (E)-N-(4-acetylphenyl)-3-(5-ethylfuran-2-yl)prop-2-enamide |
| InChI | InChI=1S/C17H17NO3/c1-3-15-8-9-16(21-15)10-11-17(20)18-14-6-4-13(5-7-14)12(2)19/h4-11H,3H2,1-2H3,(H,18,20)/b11-10+ |
| InChIKey | SPTWXRJNCFIDRQ-ZHACJKMWSA-N |
| SMILES | CCC1=CC=C(O1)/C=C/C(=O)NC2=CC=C(C=C2)C(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
