For research use only. Not for therapeutic Use.
hDHODH-IN-13 (CAT: I040308) is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH), a mitochondrial enzyme essential for de novo pyrimidine biosynthesis. It exhibits an IC₅₀ value of 173.4 nM, effectively suppressing hDHODH enzymatic activity. By disrupting pyrimidine synthesis, hDHODH-IN-13 modulates immune cell proliferation and inflammatory responses, making it a promising candidate for inflammatory disease research. Notably, it is being explored for its potential therapeutic relevance in inflammatory bowel disease (IBD). hDHODH-IN-13 is a valuable molecular probe for studying mitochondrial metabolism, immune regulation, and inflammation-associated pathologies.
| CAS Number | 3032611-13-2 |
| Synonyms | 2-[1-[(2-chloro-6-fluorophenyl)methyl]pyrrolo[2,3-b]pyridin-3-yl]-5-cyclopropylpyrimidin-4-amine |
| Molecular Formula | C21H17ClFN5 |
| Purity | ≥95% |
| IUPAC Name | 2-[1-[(2-chloro-6-fluorophenyl)methyl]pyrrolo[2,3-b]pyridin-3-yl]-5-cyclopropylpyrimidin-4-amine |
| InChI | InChI=1S/C21H17ClFN5/c22-17-4-1-5-18(23)16(17)11-28-10-15(13-3-2-8-25-21(13)28)20-26-9-14(12-6-7-12)19(24)27-20/h1-5,8-10,12H,6-7,11H2,(H2,24,26,27) |
| InChIKey | ZESAVUVCFMDOPB-UHFFFAOYSA-N |
| SMILES | C1CC1C2=CN=C(N=C2N)C3=CN(C4=C3C=CC=N4)CC5=C(C=CC=C5Cl)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
