hDHODH-IN-1

• CAT Number: I016863
• CAS Number: 1173715-42-8
• Molecular Formula: C17H14N2O2
• Molecular Weight: 278.31
• Purity: ≥95%
• Synonyms: (Z)-2-cyano-3-hydroxy-N-(4-phenylphenyl)but-2-enamide
• InChI: InChI=1S/C17H14N2O2/c1-12(20)16(11-18)17(21)19-15-9-7-14(8-10-15)13-5-3-2-4-6-13/h2-10,20H,1H3,(H,19,21)/b16-12-
• InChIKey: MUVPBAIVOHJDOC-VBKFSLOCSA-N
• SMILES: CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C2=CC=CC=C2)O

hDHODH-IN-1(CAT: I016863) is a selective inhibitor of human dihydroorotate dehydrogenase (hDHODH), a class 2 mitochondrial enzyme essential for de novo pyrimidine biosynthesis and proliferating-cell viability. By blocking hDHODH activity, this compound disrupts nucleotide metabolism and exerts significant anti-inflammatory effects. hDHODH is a clinically validated target, with inhibition linked to therapeutic potential in cancer, multiple sclerosis, autoimmune disorders, and inflammatory diseases. hDHODH-IN-1 provides a valuable research tool for exploring metabolic vulnerabilities of rapidly dividing cells and for investigating pyrimidine biosynthesis–dependent signaling pathways. Its pharmacological profile makes it a promising lead for drug discovery in oncology and immune-mediated disease research.