For research use only. Not for therapeutic Use.
HDAC6 degrader-1 (Cat No.: I045316) is a small-molecule proteolysis-targeting chimera (PROTAC) designed to selectively degrade histone deacetylase 6 (HDAC6), an enzyme involved in protein homeostasis, cell motility, and stress responses. Unlike conventional inhibitors, this degrader recruits an E3 ubiquitin ligase to tag HDAC6 for proteasomal degradation, resulting in sustained target depletion. It enhances acetylation of α-tubulin and disrupts oncogenic signaling, showing promise in cancer and neurodegenerative disease models. HDAC6 degrader-1 is a valuable research tool for probing epigenetic regulation and targeted protein degradation.
| CAS Number | 2439058-23-6 |
| Synonyms | 4-[[4-[1-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]triazol-4-yl]butyl-(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide |
| Molecular Formula | C40H45N9O9 |
| Purity | ≥95% |
| InChI | InChI=1S/C40H45N9O9/c50-34-17-16-33(37(52)43-34)49-38(53)31-10-6-11-32(35(31)39(49)54)41-18-21-57-23-24-58-22-20-48-26-30(44-46-48)9-4-5-19-47(40(55)42-29-7-2-1-3-8-29)25-27-12-14-28(15-13-27)36(51)45-56/h1-3,6-8,10-15,26,33,41,56H,4-5,9,16-25H2,(H,42,55)(H,45,51)(H,43,50,52) |
| InChIKey | NLVMRCQAKUCFIA-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCN4C=C(N=N4)CCCCN(CC5=CC=C(C=C5)C(=O)NO)C(=O)NC6=CC=CC=C6 |
| Reference | [1]. An Z, et al. Developing potent PROTACs tools for selective degradation of HDAC6 protein [published correction appears in Protein Cell. 2019 Feb 22;:]. Protein Cell. 2019;10(8):606-609. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
