For research use only. Not for therapeutic Use.
HDAC/JAK/BRD4-IN-1(CAT: I040563) is a multifunctional small molecule inhibitor that simultaneously targets histone deacetylases (HDACs), Janus kinases (JAKs), and bromodomain-containing protein 4 (BRD4). By disrupting these key epigenetic and signaling regulators, the compound exerts potent anti-inflammatory and antitumor effects. HDAC inhibition alters chromatin structure and gene expression; JAK inhibition modulates cytokine signaling; and BRD4 inhibition suppresses oncogene transcription such as MYC. This triple-action mechanism makes HDAC/JAK/BRD4-IN-1 a valuable tool for studying complex disease networks, including hematologic malignancies, solid tumors, and immune-related disorders. It offers a powerful platform for research into combination therapies and epigenetic regulation in cancer biology.
| CAS Number | 2755325-84-7 |
| Synonyms | N-hydroxy-4-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzamide |
| Molecular Formula | C24H28N6O3 |
| Purity | ≥95% |
| IUPAC Name | N-hydroxy-4-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzamide |
| InChI | InChI=1S/C24H28N6O3/c1-17-16-25-24(28-22(17)26-19-6-4-18(5-7-19)23(31)29-32)27-20-8-10-21(11-9-20)33-15-14-30-12-2-3-13-30/h4-11,16,32H,2-3,12-15H2,1H3,(H,29,31)(H2,25,26,27,28) |
| InChIKey | JUIHREVFVXLZPR-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(N=C1NC2=CC=C(C=C2)C(=O)NO)NC3=CC=C(C=C3)OCCN4CCCC4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
