Hcyb1

• CAT Number: I045318
• CAS Number: 2988566-71-6
• Molecular Formula: C24H20N4O
• Molecular Weight: 380.44
• Purity: ≥95%
• Synonyms: 2-benzyl-9-(1-naphthalen-1-ylethyl)-1H-purin-6-one
• InChI: InChI=1S/C24H20N4O/c1-16(19-13-7-11-18-10-5-6-12-20(18)19)28-15-25-22-23(28)26-21(27-24(22)29)14-17-8-3-2-4-9-17/h2-13,15-16H,14H2,1H3,(H,26,27,29)
• InChIKey: CJQKPYUNZSUCKT-UHFFFAOYSA-N
• SMILES: CC(C1=CC=CC2=CC=CC=C21)N3C=NC4=C3N=C(NC4=O)CC5=CC=CC=C5

Hcyb1 (Cat No.: I045318), also known as CYB5R1 or cytochrome b5 reductase 1, is an enzyme involved in electron transport and redox metabolism. It plays a crucial role in maintaining cellular redox balance by transferring electrons from NADH to cytochrome b5, impacting lipid metabolism, drug detoxification, and oxidative stress response. Dysregulation of Hcyb1 has been associated with cancer progression, particularly through modulation of reactive oxygen species (ROS) levels, influencing tumor cell survival, proliferation, and chemoresistance.

Reference

[1]. Li Liu, et al. The neuroprotective and antidepressant-like effects of Hcyb1, a novel selective PDE2 inhibitor. CNS Neurosci Ther. 2018 Jul;24(7):652-660.
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[2]. Meng-Jia Zhu, et al. Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior. Psychopharmacology (Berl). 2020 Nov;237(11):3215-3224.
[Content Brief]