HBC525

• CAT Number: I045311
• CAS Number: 2174014-64-1
• Molecular Formula: C19H17N3O2
• Molecular Weight: 319.36
• Purity: ≥95%
• Synonyms: (E)-2-(1,3-benzoxazol-2-yl)-3-[4-[2-hydroxyethyl(methyl)amino]phenyl]prop-2-enenitrile
• InChI: InChI=1S/C19H17N3O2/c1-22(10-11-23)16-8-6-14(7-9-16)12-15(13-20)19-21-17-4-2-3-5-18(17)24-19/h2-9,12,23H,10-11H2,1H3/b15-12+
• InChIKey: PARAUTMXYRINAC-NTCAYCPXSA-N
• SMILES: CN(CCO)C1=CC=C(C=C1)C=C(C#N)C2=NC3=CC=CC=C3O2

HBC525 (Cat No.: I045311) is a small-molecule inhibitor that selectively targets histone deacetylase 6 (HDAC6), an enzyme involved in cytoskeletal dynamics, protein degradation, and cellular stress responses. By blocking HDAC6 activity, HBC525 promotes acetylation of α-tubulin and disrupts protein trafficking and aggregation, offering therapeutic potential in cancer and neurodegenerative diseases. It exhibits anti-proliferative effects in tumor cells while sparing normal cells, highlighting its specificity. HBC525 is utilized in preclinical research to explore epigenetic modulation and targeted treatment strategies with reduced systemic toxicity.

Reference

[1]. Chen X, et al. Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs. Nat Biotechnol. 2019;37(11):1287-1293.
[Content Brief]

[2]. Yu Q, et al. Genetically encoded RNA nanodevices for cellular imaging and regulation. Nanoscale. 2021;13(17):7988-8003.
[Content Brief]