For research use only. Not for therapeutic Use.
HA-155(CAT: M089801) is a potent and highly selective autotaxin (ATX) inhibitor with an IC₅₀ of 5.7 nM. By binding directly to the ATX active site, HA-155 effectively blocks the enzymatic generation of lysophosphatidic acid (LPA), a bioactive lipid mediator involved in inflammation, fibrosis, cancer progression, and thrombosis. In functional studies, HA-155 completely attenuates thrombin-mediated increases in platelet-derived LPA in a dose-dependent manner, highlighting its strong pharmacological activity. As a valuable chemical probe, HA-155 enables detailed investigation of ATX–LPA signaling and provides a foundation for exploring therapeutic strategies targeting ATX in oncology, cardiovascular disease, and inflammatory disorders.
| CAS Number | 1312201-00-5 |
| Molecular Formula | C24H19BFNO5S |
| Purity | ≥95% |
| IUPAC Name | [4-[[4-[(Z)-[3-[(4-fluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methyl]phenyl]boronic acid |
| InChI | InChI=1S/C24H19BFNO5S/c26-20-9-3-17(4-10-20)14-27-23(28)22(33-24(27)29)13-16-5-11-21(12-6-16)32-15-18-1-7-19(8-2-18)25(30)31/h1-13,30-31H,14-15H2/b22-13- |
| InChIKey | BRWUZCBSWABPMR-XKZIYDEJSA-N |
| SMILES | B(C1=CC=C(C=C1)COC2=CC=C(C=C2)/C=C\3/C(=O)N(C(=O)S3)CC4=CC=C(C=C4)F)(O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
