H3K4(Me2) (1-20)

• CAT Number: P000337
• Molecular Formula: C93H171N35O27
• Molecular Weight: 2211.61
• Purity: ≥95%
• IUPAC Name: [(2S)-5-amino-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S,3R)-1-[[2-[[2-[[(2S)-6-amino-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-5-amino-1-[[(1S)-1-carboxy-3-methylbutyl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]-[(1R)-1-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-5-(dimethylamino)pentyl]-oxoazanium
• InChI: InChI=1S/C92H169N35O27/c1-47(2)43-61(89(152)153)119-80(143)60(31-33-65(97)132)117-76(139)55(24-12-16-36-94)115-78(141)58(27-20-39-106-91(101)102)118-83(146)63-29-22-42-126(63)88(151)50(5)111-75(138)54(23-11-15-35-93)112-69(135)45-108-68(134)44-109-85(148)70(51(6)129)122-82(145)62(46-128)120-79(142)56(25-13-17-37-95)116-77(140)57(26-19-38-105-90(99)100)114-74(137)49(4)110-86(149)71(52(7)130)124-84(147)64(32-34-66(98)133)127(154)67(30-14-18-41-125(9)10)121-87(150)72(53(8)131)123-81(144)59(113-73(136)48(3)96)28-21-40-107-92(103)104/h47-64,67,70-72,128-131H,11-46,93-96H2,1-10H3,(H33-,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,152,153)/p+1/t48-,49-,50-,51+,52+,53+,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,67+,70-,71-,72-/m0/s1
• InChIKey: MXGDKURIUGBMLI-GOAACXCSSA-O
• SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CCCCN(C)C)[N+](=O)[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)O

H3K4(Me2) (1-20)（Cat No.:P000337）is a synthetic peptide corresponding to the first 20 amino acids of histone H3, with lysine 4 specifically dimethylated. This epigenetic modification is commonly associated with gene regulation, marking both active and poised promoter regions. The peptide is widely employed in studies of histone methylation recognition, protein–histone interactions, and chromatin remodeling. By serving as a defined substrate, H3K4(Me2) (1-20) allows researchers to dissect the role of dimethylated H3K4 in transcriptional control, epigenetic signaling, and the broader regulation of chromatin structure and gene expression.