H2L 5765834

• CAT Number: I011044
• CAS Number: 420841-84-5
• Molecular Formula: C21H12N2O7
• Molecular Weight: 404.33
• Purity: ≥95%
• Synonyms: 2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxoisoindole-5-carboxylic acid
• InChI: InChI=1S/C21H12N2O7/c24-19-17-9-4-12(21(26)27)10-18(17)20(25)22(19)14-2-1-3-16(11-14)30-15-7-5-13(6-8-15)23(28)29/h1-11H,(H,26,27)
• InChIKey: HFYPTENHTPNXGP-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)OC2=CC=C(C=C2)[N+](=O)[O-])N3C(=O)C4=C(C3=O)C=C(C=C4)C(=O)O

H2L 5765834（Cat No.:I011044）is a selective small-molecule antagonist of the serotonin 5-HT2B receptor, a G protein–coupled receptor implicated in cardiovascular regulation, fibrosis, and migraine pathology. By blocking 5-HT2B–mediated signaling, it inhibits downstream pathways involved in vasoconstriction, fibroblast proliferation, and tissue remodeling. This compound has been studied in models of pulmonary arterial hypertension, cardiac valvulopathy, and fibrotic diseases, where 5-HT2B activity plays a pathogenic role. As a research tool, H2L 5765834 is valuable for dissecting serotonergic signaling, validating therapeutic targets, and exploring drug safety in cardiovascular and fibrotic disorders.