H-L-Lys(4-N3-Z)-OH hydrochloride

• CAT Number: I042584
• CAS Number: 2084913-49-3
• Molecular Formula: C14H20ClN5O4
• Molecular Weight: 357.79
• Purity: ≥95%
• Synonyms: (2S)-2-amino-6-[(4-azidophenyl)methoxycarbonylamino]hexanoic acid;hydrochloride
• InChI: InChI=1S/C14H19N5O4.ClH/c15-12(13(20)21)3-1-2-8-17-14(22)23-9-10-4-6-11(7-5-10)18-19-16;/h4-7,12H,1-3,8-9,15H2,(H,17,22)(H,20,21);1H/t12-;/m0./s1
• InChIKey: AQUASNYNCOKBBC-YDALLXLXSA-N
• SMILES: C1=CC(=CC=C1COC(=O)NCCCCC(C(=O)O)N)N=[N+]=[N-].Cl

H-L-Lys(4-N₃-Z)-OH hydrochloride (Cat No.: I042584) is a synthetic amino acid derivative of L-lysine featuring an azide group at the ε-amino position (4-position) protected by a benzyloxycarbonyl (Z) group. The azide functionality enables bioorthogonal conjugation via click chemistry, while the Z-protection provides stability during peptide synthesis. The hydrochloride salt enhances solubility and ease of handling. This compound is valuable for site-specific labeling, crosslinking, and developing functionalized peptides or proteins in chemical biology, medicinal chemistry, and advanced bioconjugation research.

Reference

[1]. Ge Y, et, al. A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells. Chem Sci. 2016 Dec 1;7(12):7055-7060.
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[2]. Wesalo JS, et, al. Phosphine-Activated Lysine Analogues for Fast Chemical Control of Protein Subcellular Localization and Protein SUMOylation. Chembiochem. 2020 Jan 15;21(1-2):141-148.
[Content Brief]