H-(Gly)3-Lys(N3)-OH hydrochloride

• CAT Number: I042582
• CAS Number: 2737202-70-7
• Molecular Formula: C12H22ClN7O5
• Molecular Weight: 379.80
• Purity: ≥95%
• Synonyms: (2S)-2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-6-azidohexanoic acid;hydrochloride
• InChI: InChI=1S/C12H21N7O5.ClH/c13-5-9(20)15-6-10(21)16-7-11(22)18-8(12(23)24)3-1-2-4-17-19-14;/h8H,1-7,13H2,(H,15,20)(H,16,21)(H,18,22)(H,23,24);1H/t8-;/m0./s1
• InChIKey: FHWDRASZJQHVLA-QRPNPIFTSA-N
• SMILES: C(CCN=[N+]=[N-])CC(C(=O)O)NC(=O)CNC(=O)CNC(=O)CN.Cl

H-(Gly)₃-Lys(N₃)-OH hydrochloride (Cat No.: I042582) is a synthetic peptide consisting of three glycine residues followed by a lysine modified with an azide (-N₃) group on its side chain. The hydrochloride salt enhances solubility and stability. This azide-functionalized tetrapeptide is widely used in bioorthogonal chemistry, especially in copper-free click reactions with alkyne-containing molecules. It serves as a versatile building block for bioconjugation, labeling, and drug delivery applications, enabling site-specific attachment of functional moieties in peptide, protein, or material science research.

Reference

[1]. Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.
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