H-Asn(glcnac-beta-D)-OH

• CAT Number: I042450
• CAS Number: 2776-93-4
• Molecular Formula: C12H21N3O8
• Molecular Weight: 335.31
• Purity: ≥95%
• Synonyms: (2S)-4-[[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]amino]-2-amino-4-oxobutanoic acid
• InChI: InChI=1S/C12H21N3O8/c1-4(17)14-8-10(20)9(19)6(3-16)23-11(8)15-7(18)2-5(13)12(21)22/h5-6,8-11,16,19-20H,2-3,13H2,1H3,(H,14,17)(H,15,18)(H,21,22)/t5-,6+,8+,9+,10+,11+/m0/s1
• InChIKey: YTTRPBWEMMPYSW-HRRFRDKFSA-N
• SMILES: CC(=O)NC1C(C(C(OC1NC(=O)CC(C(=O)O)N)CO)O)O

H-Asn(GlcNAc-β-D)-OH (Cat No.: I042450) is a synthetic glycosylated amino acid composed of asparagine (Asn) conjugated to N-acetyl-β-D-glucosamine (GlcNAc), mimicking the core structure of N-linked glycosylation found in proteins. It is used in glycoprotein synthesis, structural biology, and studies of protein folding, stability, and cell signaling. The β-glycosidic linkage to Asn reflects natural glycosylation motifs, making it valuable for producing homogeneous glycopeptides or for enzymatic and biochemical investigations into glycosylation-dependent cellular processes and therapeutic protein engineering.

Reference

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.
[Content Brief]

[2]. Haijes HA, et al. Aspartylglycosamine is a biomarker for NGLY1-CDDG, a congenital disorder of deglycosylation. Mol Genet Metab. 2019 Aug;127(4):368-372.
[Content Brief]