For research use only. Not for therapeutic Use.
GX-201 (Cat No.: I028539) is a small-molecule stimulator of soluble guanylate cyclase (sGC), an enzyme that catalyzes the conversion of GTP to cyclic GMP, a key secondary messenger regulating vascular tone, platelet function, and cellular signaling. By directly activating sGC, GX-201 increases cGMP levels independently of nitric oxide, promoting vasodilation and improving blood flow. It is investigated for potential therapeutic applications in cardiovascular and pulmonary diseases, such as pulmonary hypertension and heart failure, and serves as a research tool for studying cGMP-mediated signaling pathways.
| CAS Number | 1788071-27-1 |
| Synonyms | 4-[[1-[[2-chloro-5-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]methoxy]-5-cyclopropyl-2-fluoro-N-methylsulfonylbenzamide |
| Molecular Formula | C25H27ClF4N2O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C25H27ClF4N2O4S/c1-37(34,35)31-24(33)20-11-19(16-2-3-16)23(12-22(20)27)36-14-15-6-8-32(9-7-15)13-17-10-18(25(28,29)30)4-5-21(17)26/h4-5,10-12,15-16H,2-3,6-9,13-14H2,1H3,(H,31,33) |
| InChIKey | KYBPOTYVFWNSGS-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)NC(=O)C1=C(C=C(C(=C1)C2CC2)OCC3CCN(CC3)CC4=C(C=CC(=C4)C(F)(F)F)Cl)F |
| Reference | [1]. Girish Bankar, et al. Selective Na V 1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain. Cell Rep. 2018 Sep 18;24(12):3133-3145. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
