For research use only. Not for therapeutic Use.
GW806742X hydrochloride (Cat No.: I045611) is a potent and selective inhibitor of the receptor tyrosine kinase RON (Recepteur d’Origine Nantais, also known as MST1R). By blocking RON activity, it suppresses downstream signaling pathways including PI3K/AKT and MAPK/ERK, which are implicated in tumor cell proliferation, migration, and survival. It has been used in oncology research to investigate RON-driven tumorigenesis, therapeutic resistance, and receptor cross-talk with MET. The hydrochloride salt improves solubility and handling, making GW806742X hydrochloride a valuable probe for cancer biology studies.
| Synonyms | 1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea;hydrochloride |
| Molecular Formula | C25H23ClF3N7O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C25H22F3N7O4S.ClH/c1-35(22-13-14-30-23(34-22)31-18-3-2-4-21(15-18)40(29,37)38)19-9-5-16(6-10-19)32-24(36)33-17-7-11-20(12-8-17)39-25(26,27)28;/h2-15H,1H3,(H2,29,37,38)(H,30,31,34)(H2,32,33,36);1H |
| InChIKey | RXKWLRYRNSVTJY-UHFFFAOYSA-N |
| SMILES | CN(C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)OC(F)(F)F)C3=NC(=NC=C3)NC4=CC(=CC=C4)S(=O)(=O)N.Cl |
| Reference | [1]. Hildebrand JM, et al. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A. 2014;111(42):15072-15077. [2]. Sammond DM, et al. Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase. Bioorg Med Chem Lett. 2005;15(15):3519-3523. |
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