GW406108X

• CAT Number: I045576
• CAS Number: 1644443-92-4
• Molecular Formula: C20H11Cl2NO4
• Molecular Weight: 400.21
• Purity: ≥95%
• Synonyms: (3Z)-3-[(3,5-dichloro-4-hydroxyphenyl)methylidene]-5-(furan-2-carbonyl)-1H-indol-2-one
• InChI: InChI=1S/C20H11Cl2NO4/c21-14-7-10(8-15(22)19(14)25)6-13-12-9-11(3-4-16(12)23-20(13)26)18(24)17-2-1-5-27-17/h1-9,25H,(H,23,26)/b13-6-
• InChIKey: XKTUKRBLWOHYIL-MLPAPPSSSA-N
• SMILES: C1=COC(=C1)C(=O)C2=CC3=C(C=C2)NC(=O)C3=CC4=CC(=C(C(=C4)Cl)O)Cl

GW406108X (Cat No.: I045576) is a selective and potent inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, a critical mediator of cell growth, survival, and proliferation. By targeting EGFR signaling, GW406108X suppresses downstream pathways such as MAPK and PI3K/AKT, making it a valuable tool for studying oncogenic signaling and drug resistance mechanisms. It has been widely employed in cancer research to explore EGFR-dependent tumor biology and assess therapeutic strategies for targeting aberrant receptor tyrosine kinase activity in disease models.

Reference

[1]. Zachari M, et al. The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets. Biochem J. 2020;477(4):801-814.
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[2]. Dumas ME, et al. Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes. Bioorg Med Chem Lett. 2019;29(2):148-154.
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