GW274150 phosphate

• CAT Number: I016430
• CAS Number: 438542-15-5
• Molecular Formula: C8H20N3O6PS
• Molecular Weight: 317.30
• Purity: ≥95%
• Synonyms: (2S)-2-amino-4-[2-(1-aminoethylideneamino)ethylsulfanyl]butanoic acid;phosphoric acid
• InChI: InChI=1S/C8H17N3O2S.H3O4P/c1-6(9)11-3-5-14-4-2-7(10)8(12)13;1-5(2,3)4/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);(H3,1,2,3,4)/t7-;/m0./s1
• InChIKey: CNNHVSBCHOIDCA-FJXQXJEOSA-N
• SMILES: CC(=NCCSCCC(C(=O)O)N)N.OP(=O)(O)O

GW274150 phosphate(CAT: I016430) is a potent, selective, and orally active inducible nitric oxide synthase (iNOS) inhibitor that acts in an NADPH-dependent manner. It inhibits human iNOS with an IC₅₀ of 2.19 μM and a Kd of 40 nM, while also suppressing rat iNOS with an ED₅₀ of 1.15 μM. Importantly, it shows significantly lower potency toward endothelial NOS (eNOS) and neuronal NOS (nNOS), highlighting its selectivity. GW274150 phosphate has demonstrated protective effects in acute lung injury models, where iNOS-mediated nitric oxide production drives inflammation. This compound is a valuable tool for studying inflammation, immunology, and cardiovascular disease research.