Guanylyl imidodiphosphate lithium

• CAT Number: I044105
• CAS Number: 64564-03-0
• Molecular Formula: C10H13Li4N6O13P3
• Molecular Weight: 545.93
• Purity: ≥95%
• Synonyms: tetralithium;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-(phosphonatoamino)phosphinate
• IUPAC Name: tetralithium;[[5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-(phosphonatoamino)phosphinate
• InChI: InChI=1S/C10H17N6O13P3.4Li/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22;;;;/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24);;;;/q;4*+1/p-4
• InChIKey: NUKFMILQQVRELO-UHFFFAOYSA-J
• SMILES: [Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)(NP(=O)([O-])[O-])[O-])O)O)N=C(NC2=O)N

Guanylyl imidodiphosphate lithium (Cat No.:I044105) is a non-hydrolyzable analog of guanosine triphosphate (GTP), widely used as a biochemical tool to study G protein-coupled receptor (GPCR) signaling and GTPase activity. By mimicking GTP while resisting hydrolysis, GppNHp stabilizes GTP-binding proteins like G-proteins in their active state, enabling analysis of signal transduction mechanisms and protein conformational dynamics. Supplied as the lithium salt, it offers improved solubility for in vitro assays. Guanylyl imidodiphosphate is essential in cell signaling research, particularly in investigating GTPase cycles, receptor coupling, and enzyme activation pathways.