GSK963

• CAT Number: I019551
• CAS Number: 2049868-46-2
• Molecular Formula: C₁₄H₁₈N₂O
• Molecular Weight: 230.31
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 2,2-dimethyl-1-[(3S)-3-phenyl-3,4-dihydropyrazol-2-yl]propan-1-one
• InChI: InChI=1S/C14H18N2O/c1-14(2,3)13(17)16-12(9-10-15-16)11-7-5-4-6-8-11/h4-8,10,12H,9H2,1-3H3/t12-/m0/s1
• InChIKey: NJQVSLWJBLPTMD-LBPRGKRZSA-N
• SMILES: CC(C)(C)C(=O)N1C(CC=N1)C2=CC=CC=C2

GSK’963 (Cat No.:I019551) is a chiral small molecule inhibitor of RIP1 kinase (RIPK1), with IC50 value of 29 nM in FP binding assay. It is more than 10,000-fold selective for RIP1 over 339 other kinases. GSK’963 can maintain a certain blood concentration and inhibit 90% of RIP1 activity, compared with Nec-1, the duration of action is longer.

Reference

[1]. Berger SB, et al. Characterization of GSK’963: a structurally distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015 Jul 27;1:15009.