For research use only. Not for therapeutic Use.
GSK962（Cat No.:I017998）is a selective small-molecule antagonist of the retinoic acid receptor–related orphan receptor gamma t (RORγt), a nuclear receptor that regulates differentiation and function of Th17 cells. By blocking RORγt activity, GSK962 reduces interleukin-17 (IL-17) production, making it a valuable compound for studying autoimmune and inflammatory pathways. It has been applied in research on conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. GSK962 is an important tool for immunology studies. Supplied strictly for laboratory research purposes, not for therapeutic or diagnostic use.
| CAS Number | 2049872-86-6 |
| Synonyms | 2,2-dimethyl-1-[(3R)-3-phenyl-3,4-dihydropyrazol-2-yl]propan-1-one |
| Molecular Formula | C14H18N2O |
| Purity | ≥95% |
| IUPAC Name | 2,2-dimethyl-1-[(3R)-3-phenyl-3,4-dihydropyrazol-2-yl]propan-1-one |
| InChI | InChI=1S/C14H18N2O/c1-14(2,3)13(17)16-12(9-10-15-16)11-7-5-4-6-8-11/h4-8,10,12H,9H2,1-3H3/t12-/m1/s1 |
| InChIKey | NJQVSLWJBLPTMD-GFCCVEGCSA-N |
| SMILES | CC(C)(C)C(=O)N1[C@H](CC=N1)C2=CC=CC=C2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
