For research use only. Not for therapeutic Use.
GSK852 (Cat No.: I045558) is a small-molecule inhibitor of receptor-interacting protein kinase 3 (RIPK3), a critical regulator of programmed necrosis (necroptosis). By blocking RIPK3 activity, GSK852 prevents phosphorylation of MLKL, thereby suppressing necroptotic cell death pathways. It is widely used in research to dissect the roles of RIPK3 and necroptosis in inflammation, immunity, and disease progression. GSK852 provides a powerful tool for exploring therapeutic strategies aimed at modulating cell death mechanisms in conditions such as neurodegeneration, ischemic injury, and inflammatory disorders.
| CAS Number | 2305842-30-0 |
| Synonyms | (3S)-5-N-[(1R,5S)-3-hydroxy-6-bicyclo[3.1.0]hexanyl]-7-N,3-dimethyl-3-phenyl-2H-1-benzofuran-5,7-dicarboxamide |
| Molecular Formula | C24H26N2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H26N2O4/c1-24(14-6-4-3-5-7-14)12-30-21-18(23(29)25-2)8-13(9-19(21)24)22(28)26-20-16-10-15(27)11-17(16)20/h3-9,15-17,20,27H,10-12H2,1-2H3,(H,25,29)(H,26,28)/t15?,16-,17+,20?,24-/m0/s1 |
| InChIKey | FNHHVPPSBFQMEL-KQHDFZBMSA-N |
| SMILES | CC1(COC2=C(C=C(C=C21)C(=O)NC3C4C3CC(C4)O)C(=O)NC)C5=CC=CC=C5 |
| Reference | [1]. Lucas SCC, et al. Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors. J Med Chem. 2021 Aug 12;64(15):10711-10741. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
