GSK840 (Cat No.:I019282) is a potent inhibitor of receptor-interacting protein kinase 3 (RIP3 or RIPK3). It binds to the kinase domain of RIP3 with high affinity, exhibiting an IC50 of 0.9 nM. Additionally, GSK840 effectively inhibits the kinase activity of RIP3, with an IC50 value of 0.3 nM. By targeting RIP3, this compound holds the potential for modulating cell death pathways and has implications in various disease contexts, including inflammatory and immune-related disorders.
| Catalog Number | I019282 |
| CAS Number | 2361146-30-5 |
| Molecular Formula | C₂₁H₂₃N₃O₃ |
| Purity | 95% |
| Storage | Store at -20°C |
| IUPAC Name | tert-butyl 2-[4-[5-(methylcarbamoyl)benzimidazol-1-yl]phenyl]acetate |
| InChI | InChI=1S/C21H23N3O3/c1-21(2,3)27-19(25)11-14-5-8-16(9-6-14)24-13-23-17-12-15(20(26)22-4)7-10-18(17)24/h5-10,12-13H,11H2,1-4H3,(H,22,26) |
| InChIKey | UGTLDBJIOSYXRR-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)CC1=CC=C(C=C1)N2C=NC3=C2C=CC(=C3)C(=O)NC |
| Reference | [1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95. |
