For research use only. Not for therapeutic Use.
GSK717（Cat No.:I014907）is a potent and selective inhibitor of NOD2 (nucleotide-binding oligomerization domain-containing protein 2), an intracellular pattern-recognition receptor involved in innate immunity and inflammatory responses. By blocking NOD2 signaling, GSK717 reduces NF-κB activation and pro-inflammatory cytokine release, making it a valuable tool for studying host–pathogen interactions, autoinflammatory disorders, and Crohn’s disease mechanisms. Preclinical studies also suggest potential applications in modulating immune responses to bacterial infection and inflammation-driven pathology. GSK717’s specificity highlights its utility in exploring therapeutic strategies targeting NOD2-associated diseases and immune regulation.
| CAS Number | 1595278-21-9 |
| Synonyms | N-[2-[1-[2-(2,3-dihydro-1H-inden-5-ylamino)-2-oxoethyl]benzimidazol-2-yl]ethyl]-N-methylbenzamide |
| Molecular Formula | C28H28N4O2 |
| Purity | ≥95% |
| IUPAC Name | N-[2-[1-[2-(2,3-dihydro-1H-inden-5-ylamino)-2-oxoethyl]benzimidazol-2-yl]ethyl]-N-methylbenzamide |
| InChI | InChI=1S/C28H28N4O2/c1-31(28(34)21-8-3-2-4-9-21)17-16-26-30-24-12-5-6-13-25(24)32(26)19-27(33)29-23-15-14-20-10-7-11-22(20)18-23/h2-6,8-9,12-15,18H,7,10-11,16-17,19H2,1H3,(H,29,33) |
| InChIKey | YDOATJUIIFWTKQ-UHFFFAOYSA-N |
| SMILES | CN(CCC1=NC2=CC=CC=C2N1CC(=O)NC3=CC4=C(CCC4)C=C3)C(=O)C5=CC=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
