GSK547 - CAS 2226735-55-1

GSK’547(Cat No.:I019199) is a highly selective and potent inhibitor of receptor-interacting protein kinase 1 (RIP1 or RIPK1). It exhibits a significant increase in oral exposure, approximately 400-fold, compared to GSK’963 based on a mouse pharmacokinetic study. By targeting RIP1, GSK’547 holds the potential in modulating cell death pathways and inflammatory responses. The increased oral exposure to GSK’547 suggests improved bioavailability, which may enhance its therapeutic efficacy.

Catalog Number: I019199

CAS Number: 2226735-55-1

Molecular Formula: C₂₀H₁₈F₂N₆O

Molecular Weight:396.39

Purity: ≥95%

* For research use only. Not for human or veterinary use.


Property

Molecular Formula: C₂₀H₁₈F₂N₆O
Molecular Weight396.39
Purity≥95%
StorageStore at -20°C

Computed Descriptor

IUPAC Name6-[4-[(3S)-3-(3,5-difluorophenyl)-3,4-dihydropyrazole-2-carbonyl]piperidin-1-yl]pyrimidine-4-carbonitrile
InChIInChI=1S/C20H18F2N6O/c21-15-7-14(8-16(22)9-15)18-1-4-26-28(18)20(29)13-2-5-27(6-3-13)19-10-17(11-23)24-12-25-19/h4,7-10,12-13,18H,1-3,5-6H2/t18-/m0/s1
InChIKeySJVGFKBLUYAEOK-SFHVURJKSA-N
SMILESC1CN(CCC1C(=O)N2C(CC=N2)C3=CC(=CC(=C3)F)F)C4=NC=NC(=C4)C#N