GSK3145095 - CAS 1622849-43-7

GSK3145095(Cat No.:I019224) is a potent and orally active inhibitor of RIP1 kinase, an enzyme involved in regulating cell death and inflammation. It demonstrates an inhibitory concentration (IC50) of 6.3 nM against RIP1 kinase. By targeting RIP1 kinase, GSK3145095 exhibits potential antitumor effects by promoting cancer cell death and also possesses immunomodulatory properties by regulating inflammatory responses. This compound holds promise as a therapeutic agent for the treatment of various diseases, including cancer, where dysregulation of RIP1 kinase signaling is implicated.

Catalog Number: I019224

CAS Number: 1622849-43-7

Molecular Formula: C₂₀H₁₇F₂N₅O₂

Molecular Weight:397.38

Purity: ≥95%

* For research use only. Not for human or veterinary use.


Property

Molecular Formula: C₂₀H₁₇F₂N₅O₂
Molecular Weight397.38
Purity≥95%
StorageStore at -20°C

Computed Descriptor

IUPAC Name5-benzyl-N-[(3S)-7,9-difluoro-2-oxo-1,3,4,5-tetrahydro-1-benzazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide
InChIInChI=1S/C20H17F2N5O2/c21-13-9-12-6-7-15(19(28)25-17(12)14(22)10-13)23-20(29)18-24-16(26-27-18)8-11-4-2-1-3-5-11/h1-5,9-10,15H,6-8H2,(H,23,29)(H,25,28)(H,24,26,27)/t15-/m0/s1
InChIKeyATQAGKAMBISZQM-HNNXBMFYSA-N
SMILESC1CC2=C(C(=CC(=C2)F)F)NC(=O)C1NC(=O)C3=NNC(=N3)CC4=CC=CC=C4