For research use only. Not for therapeutic Use.
GSK2879552 dihydrochloride（Cat No.:I015338）is a selective, irreversible inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A), an epigenetic enzyme that demethylates histone H3 lysine 4 (H3K4). By blocking LSD1 activity, it modulates gene expression programs linked to cancer cell proliferation and differentiation. Developed by GlaxoSmithKline, GSK2879552 has been investigated in clinical trials for small cell lung cancer, acute myeloid leukemia, and other malignancies where LSD1 is dysregulated. The dihydrochloride salt enhances solubility and stability for research use. It is a valuable tool for studying epigenetic regulation and therapeutic strategies targeting chromatin-modifying enzymes.
| CAS Number | 1902123-72-1 |
| Synonyms | 4-[[4-[[[(1R,2S)-2-phenylcyclopropyl]amino]methyl]piperidin-1-yl]methyl]benzoic acid;dihydrochloride |
| Molecular Formula | C23H30Cl2N2O2 |
| Purity | ≥95% |
| IUPAC Name | 4-[[4-[[[(1R,2S)-2-phenylcyclopropyl]amino]methyl]piperidin-1-yl]methyl]benzoic acid;dihydrochloride |
| InChI | InChI=1S/C23H28N2O2.2ClH/c26-23(27)20-8-6-18(7-9-20)16-25-12-10-17(11-13-25)15-24-22-14-21(22)19-4-2-1-3-5-19;;/h1-9,17,21-22,24H,10-16H2,(H,26,27);2*1H/t21-,22+;;/m0../s1 |
| InChIKey | QEKGSBZKRLHQSZ-VSIGASKDSA-N |
| SMILES | C1CN(CCC1CN[C@@H]2C[C@H]2C3=CC=CC=C3)CC4=CC=C(C=C4)C(=O)O.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
