GSK143 dihydrochloride

• CAT Number: I015317
• CAS Number: 2341796-81-2
• Molecular Formula: C17H24Cl2N6O2
• Molecular Weight: 415.32
• Purity: ≥95%
• Synonyms: 2-[[(3R,4R)-3-aminooxan-4-yl]amino]-4-(4-methylanilino)pyrimidine-5-carboxamide;dihydrochloride
• InChI: InChI=1S/C17H22N6O2.2ClH/c1-10-2-4-11(5-3-10)21-16-12(15(19)24)8-20-17(23-16)22-14-6-7-25-9-13(14)18;;/h2-5,8,13-14H,6-7,9,18H2,1H3,(H2,19,24)(H2,20,21,22,23);2*1H/t13-,14+;;/m0../s1
• InChIKey: UEHPBSLIDBDMCZ-WICJZZOFSA-N
• SMILES: CC1=CC=C(C=C1)NC2=NC(=NC=C2C(=O)N)N[C@@H]3CCOC[C@@H]3N.Cl.Cl

GSK143 dihydrochloride（Cat No.:I015317）is a potent and selective small-molecule inhibitor of autotaxin (ENPP2), an enzyme that catalyzes the production of lysophosphatidic acid (LPA), a bioactive lipid mediator involved in cell proliferation, migration, and survival. By blocking autotaxin activity, GSK143 reduces LPA signaling, making it a valuable tool for investigating cancer progression, fibrosis, and inflammatory diseases where LPA is implicated. The dihydrochloride salt form enhances solubility and handling, supporting its use in pharmacological and biochemical studies aimed at therapeutic discovery in oncology and fibrosis research.