For research use only. Not for therapeutic Use.
GSK121（Cat No.:R065573）is a selective inhibitor of protein arginine deiminase 4 (PAD4), an enzyme that catalyzes the citrullination of arginine residues in proteins—a process implicated in gene regulation and various inflammatory diseases. Identified as an initial lead compound in PAD4 inhibitor screens, GSK121 exhibits an IC₅₀ of 3.2 µM in functional assays . Although less potent than its optimized derivatives, GSK484 and GSK199, GSK121 remains a valuable tool for studying PAD4-mediated pathways, including neutrophil extracellular trap (NET) formation and autoimmune responses .
| CAS Number | 1652591-80-4 |
| Synonyms | (3-aminopiperidin-1-yl)-[1-methyl-2-(1-methylindol-2-yl)benzimidazol-5-yl]methanone;2,2,2-trifluoroacetic acid |
| Molecular Formula | C25H26F3N5O3 |
| Purity | ≥95% |
| IUPAC Name | (3-aminopiperidin-1-yl)-[1-methyl-2-(1-methylindol-2-yl)benzimidazol-5-yl]methanone;2,2,2-trifluoroacetic acid |
| InChI | InChI=1S/C23H25N5O.C2HF3O2/c1-26-19-8-4-3-6-15(19)13-21(26)22-25-18-12-16(9-10-20(18)27(22)2)23(29)28-11-5-7-17(24)14-28;3-2(4,5)1(6)7/h3-4,6,8-10,12-13,17H,5,7,11,14,24H2,1-2H3;(H,6,7) |
| InChIKey | CUCLWQZRCAQPJM-UHFFFAOYSA-N |
| SMILES | CN1C2=C(C=C(C=C2)C(=O)N3CCCC(C3)N)N=C1C4=CC5=CC=CC=C5N4C.C(=O)(C(F)(F)F)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
