GSK-LSD1 Dihydrochloride

  • CAT Number: I013239
  • CAS Number: 2102933-95-7
  • Molecular Formula: C₁₄H₂₂Cl₂N₂
  • Molecular Weight: 289.24
  • Purity: ≥95%
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GSK-LSD1 Dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM.

Catalog Number I013239
CAS Number 2102933-95-7
Molecular Formula

C₁₄H₂₂Cl₂N₂

Purity 95%
Target Histone Demethylase Monoamine Oxidase
Solubility DMSO: ≥100 mg/mL
IUPAC Name N-[(1R,2S)-2-phenylcyclopropyl]piperidin-4-amine;dihydrochloride
InChI InChI=1S/C14H20N2.2ClH/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12;;/h1-5,12-16H,6-10H2;2*1H/t13-,14+;;/m0../s1
InChIKey PJFZOGMSPBHPNS-WICJZZOFSA-N
SMILES C1CNCCC1NC2CC2C3=CC=CC=C3.Cl.Cl
Reference

[1]. Purich D. The Inhibitor Index A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads. ISBN 9781138739215<br>[2]. Wang Z, et al. Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. Biochim Biophys Acta. 2017 Aug 8;1864(12):2428-2437.

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