GSK-2879552

• CAT Number: I001536
• CAS Number: 1401966-69-5
• Molecular Formula: C₂₃H₂₈N₂O₂.HCl
• Molecular Weight: 400.94
• Purity: ≥95%
• Synonyms: 4-((4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid
• Target: Histone Demethylases
• Solubility: DMSO: 31 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C23H28N2O2/c26-23(27)20-8-6-18(7-9-20)16-25-12-10-17(11-13-25)15-24-22-14-21(22)19-4-2-1-3-5-19/h1-9,17,21-22,24H,10-16H2,(H,26,27)
• InChIKey: LRULVYSBRWUVGR-UHFFFAOYSA-N
• SMILES: C1CN(CCC1CNC2CC2C3=CC=CC=C3)CC4=CC=C(C=C4)C(=O)O

GSK-2879552 (CAT: I001536) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1). LSD1 is an enzyme involved in the regulation of gene expression through histone demethylation. By inhibiting LSD1, GSK-2879552 can modulate gene expression patterns, potentially leading to antineoplastic effects. It has shown promise in preclinical studies as a therapeutic agent for the treatment of various cancers.

Reference

[1]. Mohammad HP, et al. A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69.