GSK-2879552

  • CAT Number: I001536
  • CAS Number: 1401966-69-5
  • Molecular Formula: C₂₃H₂₈N₂O₂.HCl
  • Molecular Weight: 400.94
  • Purity: ≥95%
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GSK-2879552 (CAT: I001536) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1). LSD1 is an enzyme involved in the regulation of gene expression through histone demethylation. By inhibiting LSD1, GSK-2879552 can modulate gene expression patterns, potentially leading to antineoplastic effects. It has shown promise in preclinical studies as a therapeutic agent for the treatment of various cancers.

Catalog Number I001536
CAS Number 1401966-69-5
Molecular Formula

C₂₃H₂₈N₂O₂.HCl

Purity 95%
Target Histone Demethylases
Solubility DMSO: 31 mg/mL
Storage Store at -20°C
InChI InChI=1S/C23H28N2O2/c26-23(27)20-8-6-18(7-9-20)16-25-12-10-17(11-13-25)15-24-22-14-21(22)19-4-2-1-3-5-19/h1-9,17,21-22,24H,10-16H2,(H,26,27)
InChIKey LRULVYSBRWUVGR-UHFFFAOYSA-N
SMILES C1CN(CCC1CNC2CC2C3=CC=CC=C3)CC4=CC=C(C=C4)C(=O)O
Reference

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<br>[1]. Mohammad HP, et al. A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69.

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