GSA-10

• CAT Number: R062081
• CAS Number: 300833-95-8
• Molecular Formula: C26H30N2O5
• Molecular Weight: 450.53
• Purity: ≥95%
• Synonyms: propyl 4-[(1-hexyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]benzoate
• InChI: InChI=1S/C26H30N2O5/c1-3-5-6-9-16-28-21-11-8-7-10-20(21)23(29)22(25(28)31)24(30)27-19-14-12-18(13-15-19)26(32)33-17-4-2/h7-8,10-15,29H,3-6,9,16-17H2,1-2H3,(H,27,30)
• InChIKey: MDLUYYGRCGDKGL-UHFFFAOYSA-N
• SMILES: CCCCCCN1C2=CC=CC=C2C(=C(C1=O)C(=O)NC3=CC=C(C=C3)C(=O)OCCC)O

GSA-10 (Cat No.: R062081) is a small-molecule agonist of smoothened (SMO), a key transmembrane protein in the Hedgehog (Hh) signaling pathway. By activating SMO, GSA-10 stimulates downstream Gli transcription factors, promoting gene expression involved in cell proliferation, differentiation, and tissue regeneration. It is used in developmental biology and regenerative medicine research to study Hh pathway activation and its role in stem cell biology, neurogenesis, and tissue repair. GSA-10 also serves as a tool to explore Hedgehog-related mechanisms in cancer and other pathological conditions.

Reference

[1]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol Pharmacol. 2013 May;83(5):1020-9.
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[2]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016 Oct 4;121:747-757.
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[3]. Fleury A, et al. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci Rep. 2016 Mar 24;6:23479. doi: 10.1038/srep23479. PMID: 27010359; PMCID: PMC4806302.
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