For research use only. Not for therapeutic Use.
GRL-0496（Cat No.:I044651）is a potent small-molecule inhibitor of the 3C-like protease (3CLpro or Mpro) of SARS-CoV and SARS-CoV-2, essential for viral replication. It exhibits strong enzymatic inhibition with an IC₅₀ of approximately 30 nM and effectively suppresses viral replication in cell-based assays with an EC₅₀ around 6.9 μM. Structurally a chloropyridyl ester derivative (C₁₄H₉ClN₂O₂, MW 272.7 g/mol), GRL-0496 is commonly supplied as a high-purity solid and is soluble in DMSO. It is widely used in antiviral research as a lead compound for therapeutic development against coronaviruses.
| CAS Number | 1087243-14-8 |
| Synonyms | (5-chloropyridin-3-yl) 1H-indole-4-carboxylate |
| Molecular Formula | C14H9ClN2O2 |
| Purity | ≥95% |
| IUPAC Name | (5-chloropyridin-3-yl) 1H-indole-4-carboxylate |
| InChI | InChI=1S/C14H9ClN2O2/c15-9-6-10(8-16-7-9)19-14(18)12-2-1-3-13-11(12)4-5-17-13/h1-8,17H |
| InChIKey | BOSZJNSICHFHMA-UHFFFAOYSA-N |
| SMILES | C1=CC(=C2C=CNC2=C1)C(=O)OC3=CC(=CN=C3)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
