GRK6-IN-2

• CAT Number: I044081
• CAS Number: 2677786-27-3
• Molecular Formula: C21H21FN6
• Molecular Weight: 376.43
• Purity: ≥95%
• Synonyms: 4-N-(5-ethyl-1H-pyrazol-3-yl)-2-N-[(1S)-1-(4-fluorophenyl)ethyl]quinazoline-2,4-diamine
• InChI: InChI=1S/C21H21FN6/c1-3-16-12-19(28-27-16)25-20-17-6-4-5-7-18(17)24-21(26-20)23-13(2)14-8-10-15(22)11-9-14/h4-13H,3H2,1-2H3,(H3,23,24,25,26,27,28)/t13-/m0/s1
• InChIKey: QIKJAWWGNVSEHB-ZDUSSCGKSA-N
• SMILES: CCC1=CC(=NN1)NC2=NC(=NC3=CC=CC=C32)N[C@@H](C)C4=CC=C(C=C4)F

GRK6-IN-2（Cat No.:I044081）is a potent and selective inhibitor of G protein-coupled receptor kinase 6 (GRK6), an enzyme involved in the desensitization and internalization of GPCRs through receptor phosphorylation. By targeting GRK6, this compound modulates GPCR signaling dynamics, affecting pathways relevant to immune response, inflammation, and neurodegeneration. GRK6-IN-2 is valuable in studies exploring chemokine receptor regulation, dopaminergic signaling, and autoimmune disease mechanisms. It serves as a critical tool for investigating GRK6’s role in receptor trafficking, signal bias, and for evaluating its potential as a therapeutic target in chronic inflammation and neurological disorders.