For research use only. Not for therapeutic Use.
GRK6-IN-1（Cat No.:I044082）is a selective small-molecule inhibitor of G protein-coupled receptor kinase 6 (GRK6), an essential kinase that phosphorylates activated GPCRs to regulate their desensitization, internalization, and signaling. By inhibiting GRK6, this compound enhances or sustains GPCR-mediated signaling, making it a valuable tool in studying immune cell trafficking, inflammatory responses, and neurological signaling pathways. GRK6-IN-1 is particularly relevant in autoimmune diseases and neurodegenerative disorders, where aberrant GRK6 activity contributes to pathogenesis. It supports drug discovery efforts aimed at modulating GPCR function and fine-tuning biased signaling for therapeutic applications.
| CAS Number | 2677786-61-5 |
| Synonyms | 2-N-[(4-chloro-2-methoxyphenyl)methyl]-4-N-(5-ethyl-1H-pyrazol-3-yl)-5-methoxyquinazoline-2,4-diamine |
| Molecular Formula | C22H23ClN6O2 |
| Purity | ≥95% |
| IUPAC Name | 2-N-[(4-chloro-2-methoxyphenyl)methyl]-4-N-(5-ethyl-1H-pyrazol-3-yl)-5-methoxyquinazoline-2,4-diamine |
| InChI | InChI=1S/C22H23ClN6O2/c1-4-15-11-19(29-28-15)26-21-20-16(6-5-7-17(20)30-2)25-22(27-21)24-12-13-8-9-14(23)10-18(13)31-3/h5-11H,4,12H2,1-3H3,(H3,24,25,26,27,28,29) |
| InChIKey | ACLLLJSNOCYQOJ-UHFFFAOYSA-N |
| SMILES | CCC1=CC(=NN1)NC2=NC(=NC3=C2C(=CC=C3)OC)NCC4=C(C=C(C=C4)Cl)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
