For research use only. Not for therapeutic Use.
GRK5-IN-2（Cat No.:I014903）is a potent and selective inhibitor of G protein–coupled receptor kinase 5 (GRK5), an enzyme involved in receptor desensitization, cardiovascular regulation, and cancer progression. By blocking GRK5 activity, GRK5-IN-2 modulates GPCR signaling, alters receptor phosphorylation, and influences downstream pathways linked to cardiac hypertrophy and tumor growth. This compound is a valuable tool for studying GRK5’s role in cardiovascular disease, oncology, and neurobiology. Its selectivity enables researchers to dissect GRK-mediated signaling with precision, supporting the development of targeted therapeutic strategies in diverse disease contexts.
| CAS Number | 1642839-27-7 |
| Synonyms | 2-(furan-2-yl)-1-methyl-N-(3,4,5-trimethoxyphenyl)imidazo[4,5-c]pyridin-6-amine |
| Molecular Formula | C20H20N4O4 |
| Purity | ≥95% |
| IUPAC Name | 2-(furan-2-yl)-1-methyl-N-(3,4,5-trimethoxyphenyl)imidazo[4,5-c]pyridin-6-amine |
| InChI | InChI=1S/C20H20N4O4/c1-24-14-10-18(21-11-13(14)23-20(24)15-6-5-7-28-15)22-12-8-16(25-2)19(27-4)17(9-12)26-3/h5-11H,1-4H3,(H,21,22) |
| InChIKey | CRUXKUKVTMZKSO-UHFFFAOYSA-N |
| SMILES | CN1C2=CC(=NC=C2N=C1C3=CC=CO3)NC4=CC(=C(C(=C4)OC)OC)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
