GRAVEOLINE(cas 485-61-0) is a CNS stimulant, convulsant and hypertensive.
Alkaloid, from plants of the Rutaceae family.
As CNS stimulant, it increases breath rhythm, reflex excitability and intensifies clinical cramps (tonic cramps).br>1 – 10 mg/kg increase arterial pressure by 5 – 20 mm Hg during 2 – 30 min.<br>1 – 3 – 5 mg/kg, on cats and dogs under anaesthesia, increase breath rhythm, which remains after decerebration, total excision of cerebellum and carotide ganglion block.<br>3 mg/kg and more, increase electric activity in the cortex and subcortex formations.<br>5 mg/kg remove completely the action of Thiopental sodium, Barbamil, Aminazine and Morphine on the bioelectrical activity of rabbit brain.<br>0.5 – 3mg/kg facilitate the conductivity of electric impulse in the downward activating system and stimulates the respiratory system of the reticulum formation of the caudal part of cat brain.
| Catalog Number | T000120 |
| CAS Number | 485-61-0 |
| Synonyms | 4(1H)-Quinolone,1-methyl-2-[3,4-(methylenedioxy)phenyl]- (6CI,7CI,8CI) |
| Molecular Formula | C17H13NO3 |
| Purity | 95% |
| Solubility | In chloroform and hot alcohol |
| Storage | Store at +4°C, in dark place. |
| IUPAC Name | 2-(1,3-benzodioxol-5-yl)-1-methylquinolin-4-one |
| InChI | InChI=1S/C17H13NO3/c1-18-13-5-3-2-4-12(13)15(19)9-14(18)11-6-7-16-17(8-11)21-10-20-16/h2-9H,10H2,1H3 |
| InChIKey | COBBNRKBTCBWQP-UHFFFAOYSA-N |
| SMILES | CN1C2=CC=CC=C2C(=O)C=C1C3=CC4=C(C=C3)OCO4 |
| Reference | – Ishmukamedov et al., /Foliosine influence on respiratory zones of reticular formation of caudal part of the brain./ Pharmacology of alkaloids and glycosides. (1967) Tashkent p. 26-29 (Russian). <br /> |
