GPX4-IN-2

• CAT Number: I042014
• CAS Number: 2485005-22-7
• Molecular Formula: C30H40N2O
• Molecular Weight: 444.65
• Purity: ≥95%
• Synonyms: N-[4-[(1S,3S)-3-butyl-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]phenyl]adamantan-1-amine
• InChI: InChI=1S/C30H40N2O/c1-3-4-5-26-15-24-16-27(33-2)10-11-28(24)29(31-26)23-6-8-25(9-7-23)32-30-17-20-12-21(18-30)14-22(13-20)19-30/h6-11,16,20-22,26,29,31-32H,3-5,12-15,17-19H2,1-2H3/t20?,21?,22?,26-,29-,30?/m0/s1
• InChIKey: YBBBVOMLRKBZDK-MLMUNBGCSA-N
• SMILES: CCCCC1CC2=C(C=CC(=C2)OC)C(N1)C3=CC=C(C=C3)NC45CC6CC(C4)CC(C6)C5

GPX4-IN-2 is a potent GPX4 inhibitor. GPX4 shows antiproliferative activity. GPX4-IN-2 has the potential for the research of cancer[1].
GPX4-IN-2 (compound 28) (0.0005-10 mM; 24 h) shows antiproliferative activity with IC50s of 0.004, 0.016, 2.9 µM for 786-O, SJSA-1, A431 cells, respectively[1].
GPX4-IN-2 (5 mg/kg for mouse, 2 mg/kg for rats; i.v.) shows a good pharmacokinetics profile in mice and rats[1].

Reference

[1]. Chun Jiang, et al. Compounds with ferroptosis inducing activity and methods of their use. WO2020176757A1.