For research use only. Not for therapeutic Use.
GPR84 antagonist 2（Cat No.:I044139）is a small-molecule inhibitor targeting GPR84, a G-protein-coupled receptor primarily expressed in immune cells such as macrophages and neutrophils. GPR84 is activated by medium-chain fatty acids and plays a role in pro-inflammatory signaling pathways. Antagonist 2 selectively blocks GPR84 activity, making it a valuable research tool for studying inflammation, metabolic disorders, and fibrosis. By inhibiting GPR84, this compound reduces cytokine production and immune cell activation, offering therapeutic potential in conditions like inflammatory bowel disease, non-alcoholic steatohepatitis (NASH), and autoimmune diseases. It is used extensively in preclinical pharmacological investigations.
| CAS Number | 2244269-74-5 |
| Synonyms | sodium;bis(4-chlorobenzo[b][1]benzothiepin-6-yl) phosphate |
| Molecular Formula | C28H16Cl2NaO4PS2 |
| Purity | ≥95% |
| IUPAC Name | sodium;bis(4-chlorobenzo[b][1]benzothiepin-6-yl) phosphate |
| InChI | InChI=1S/C28H17Cl2O4PS2.Na/c29-21-9-5-13-27-19(21)15-23(17-7-1-3-11-25(17)36-27)33-35(31,32)34-24-16-20-22(30)10-6-14-28(20)37-26-12-4-2-8-18(24)26;/h1-16H,(H,31,32);/q;+1/p-1 |
| InChIKey | JFIDCMUEKCPJLL-UHFFFAOYSA-M |
| SMILES | C1=CC=C2C(=C1)C(=CC3=C(S2)C=CC=C3Cl)OP(=O)([O-])OC4=CC5=C(C=CC=C5Cl)SC6=CC=CC=C64.[Na+] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
