GPR81 Agonist 1（Cat No.:I044505）is a synthetic small-molecule compound that selectively activates GPR81 (also known as hydroxycarboxylic acid receptor 1 or HCAR1), a G-protein-coupled receptor primarily expressed in adipose tissue and the brain. GPR81 is naturally activated by lactate and plays a role in inhibiting lipolysis, regulating energy metabolism, and modulating inflammatory responses. GPR81 Agonist 1 mimics lactate’s effects, providing a valuable pharmacological tool for studying metabolic diseases, obesity, diabetes, and neuroprotection. Its selective activation of GPR81 enables exploration of therapeutic strategies targeting metabolic and inflammatory disorders.